Effects By Dose 1

EFFECTS BY DOSE

NOTE: Effects listed below aren’t meant to be comprehensive, particularly at the lower dose ranges. They may be subject to change as more reliable, more widely representative data become available.

These dose ranges are for Psilocybe cubensis mushrooms. They may apply to other psilocybin-containing species, but some (e.g. P. semilanceata) are  more potent on average.

Microdose (50-250 mg)

  • Mood enhancement
  • Decreased stress
  • Emotional stability
  • Mindfulness, presence, and peace
  • Openness and self-forgiveness
  • Increased empathy and sociability
  • Conversational fluidity
  • Alleviation of persistent conditions such as depression, anxiety, ADD/ADHD, PTSD
  • Increased motivation (e.g. to make positive lifestyle changes)
  • Increased focus/productivity
  • Increased flow states
  • Clearer, more connected thinking
  • Improved memory
  • Enhanced senses
  • Enhanced appreciation for music, art, etc.
  • Increased creativity
  • Spontaneity
  • Easier meditation
  • Increased enjoyment of physical activity and everyday tasks
  • Relaxation and increased awareness of body
  • Enhanced athletic endurance
  • Increased energy overall (without anxiety or a subsequent crash)
  • Amplification of mood, positive or negative
  • Slight sedative effect
  • Possible manic states
  • Potentially increased neuroticism

Mini-dose (250-750 MG)

  • Mood enhancement, mild euphoria or excitement
  • Mindfulness, presence, and peace
  • Openness and self-forgiveness
  • Introspective insights
  • Alleviation of persistent conditions such as depression, anxiety, ADD/ADHD, PTSD
  • Increased motivation (e.g. to make positive lifestyle changes)
  • Increased flow states
  • Clearer, more connected thinking
  • Enhanced senses
  • Enhanced appreciation for music, art, etc.
  • Increased creativity
  • Spontaneity
  • Easier meditation
  • Increased enjoyment of physical activity and everyday tasks
  • Relaxation and increased awareness of body
  • Increased energy in waves
  • Mild body high
  • Amplification of mood, positive or negative
  • Preference for introspection over socializing
  • Increased sensitivity to light
  • Very mild visuals, if any
  • Possible manic states
  • Potentially increased neuroticism
  • Difficulty focusing or thought loops
  • Difficulty with some cognitive tasks
  • Anxiety, agitation, or restlessness
  • Difficulty or discomfort socializing
  • Frustration at dosage (too high to be comfortable, too low to be “recreational”)

Museum dose (500-1500 MG)

  • Mood enhancement, euphoria or excitement
  • Mild to moderate visuals (e.g. “breathing” environments)
  • Increased empathy
  • Conversational fluidity
  • Introspection
  • Increased flow states
  • Enhanced senses
  • Enhanced appreciation for music, art, etc.
  • Increased creativity
  • Spontaneity
  • Increased enjoyment of physical activity and everyday tasks
  • Finding otherwise mundane things funny or interesting
  • Enhanced athletic endurance
  • Moderate body high
  • Clear come-up, peak, and come-down
  • Amplification of mood, positive or negative
  • Altered perception of sound
  • Time dilation or contraction (time passing more slowly or quickly)
  • Increased sensitivity to light
  • Pupil dilation
  • Difficulty focusing or thought loops
  • Difficulty with some tasks
  • Difficulty or discomfort socializing
  • Frustration at dosage (at lower end)

Moderate dose (2000-3500 MG)

  • Strong euphoria or excitement
  • Sense of peace
  • Mystical experience and feelings of wonder
  • Life-changing introspective or philosophical insights
  • Increased flow of ideas
  • Increased creativity
  • Enhanced senses
  • Enhanced appreciation for music, art, etc.
  • Finding otherwise mundane things funny or interesting
  • Strong body high
  • Clear come-up, peak, and come-down
  • Amplification of emotions, whether good or bad
  • Open- and closed-eye visuals (e.g. patterns, auras)
  • Synesthesia
  • Time dilation or contraction (time passing more slowly or quickly)
  • Sedation
  • Unusual physical sensations
  • Sensitivity to light
  • Wide pupil dilation
  • Compulsive yawning
  • Confusion
  • Disorientation
  • Fear and anxiety (“bad trip” experiences)
  • Difficulty with cognitive tasks
  • Dizziness
  • Nausea

Mega Dose (5000+ MG)

  • Strong euphoria or excitement
  • Mystical experience and intense feelings of wonder
  • Life-changing introspective or philosophical insights
  • Ego death
  • Increased flow of ideas
  • Increased creativity
  • Enhanced senses
  • Finding otherwise mundane things funny or interesting
  • Very strong body high
  • Clear come-up, peak, and come-down
  • Amplification of emotions, whether good or bad
  • Very strong open- and closed-eye visions (e.g. memories coming to life)
  • Visual, auditory, tactile hallucinations
  • Synesthesia
  • Time becoming meaningless
  • Thought loops
  • Sedation
  • Unusual physical sensations and altered perception of physical form
  • Sensitivity to light
  • Very wide pupil dilation
  • Compulsive yawning
  • Confusion
  • Disorientation
  • Compromised motor functions (sitter recommended!)
  • Strong fear and anxiety (extreme “bad trip” experiences)
  • Extreme difficulty with cognitive tasks
  • Dizziness
  • Nausea
  • Light-headedness
  • Headaches

Potential Benefits

Psychedelic mushrooms have a longstanding, profound, and storied background among the many cultures that have historically used them. Today, the benefits of these powerful little fungi are being recognized in a big way. Currently, studies into the vast and multifarious use of psychoactive mushrooms are being conducted across the United States and abroad. One such study, published in the Journal of Psychopharmacology, found that, “a single dose of psilocybin produced substantial and enduring decreases in depressed mood and anxiety along with increases in quality of life […]. Additionally, the mystical and profound experiences that so many have experienced since psilocybin entered the American psychedelic lexicon in the 1960s, are now beginning to be tested and explored in mainstream medical science. The results are promising and compelling, and paint a substantiated, positive, symbiotic picture of mushrooms as a powerful healer.

Specifically, clinical trials have been, and are currently, being conducted in the United States and abroad which involve patients dealing with life-threatening cancer. These trials mainly seek to understand the efficacy of high dose psilocybin, administered in therapeutic environments, as a tool for reducing the psychological stress and anxiety that often accompanies a life-threatening diagnosis. The results so far have been promising. Under double-blind conditions, not only has a single, high-dose of psilocybin been shown to reduce symptoms of psychological distress among the terminal patient groups; the effects have been substantial and enduring.

Additionally, there is a growing body of research which suggests that part of why psilocybin is so effective is that it impacts neuroplasticity. That is, the brain’s ability to learn and grow and change.